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Under current emission trajectories, temporarily overshooting the Paris global warming limit of 1.5 °C is a distinct possibility. Permanently exceeding this limit would substantially increase the probability of triggering climate tipping elements. Here, we investigate the tipping risks associated with several policy-relevant future emission scenarios, using a stylised Earth system model of four interconnected climate tipping elements. We show that following current policies this century would commit to a 45% tipping risk by 2300 (median, 10–90% range: 23–71%), even if temperatures are brought back to below 1.5 °C. We find that tipping risk by 2300 increases with every additional 0.1 °C of overshoot above 1.5 °C and strongly accelerates for peak warming above 2.0 °C. Achieving and maintaining at least net zero greenhouse gas emissions by 2100 is paramount to minimise tipping risk in the long term. Our results underscore that stringent emission reductions in the current decade are critical for planetary stabili

AlphaFold3 peut prédire avec plus de précision comment les protéines interagissent avec d'autres molécules biologiques.

Evidence shows a continuing increase in the frequency and severity of global heatwaves1,2, raising concerns about the future impacts of climate change and the associated socioeconomic costs3,4. Here we develop a disaster footprint analytical framework by integrating climate, epidemiological and hybrid input–output and computable general equilibrium global trade models to estimate the midcentury socioeconomic impacts of heat stress. We consider health costs related to heat exposure, the value of heat-induced labour productivity loss and indirect losses due to economic disruptions cascading through supply chains. Here we show that the global annual incremental gross domestic product loss increases exponentially from 0.03 ± 0.01 (SSP 245)–0.05 ± 0.03 (SSP 585) percentage points during 2030–2040 to 0.05 ± 0.01–0.15 ± 0.04 percentage points during 2050–2060. By 2060, the expected global economic losses reach a total of 0.6–4.6% with losses attributed to health loss (37–45%), labour productivity loss (18–37%) and i

Anthropogenic emissions drive global-scale warming yet the temperature increase relative to pre-industrial levels is uncertain. Using 300 years of ocean mixed-layer temperature records preserved in sclerosponge carbonate skeletons, we demonstrate that industrial-era warming began in the mid-1860s, more than 80 years earlier than instrumental sea surface temperature records. The Sr/Ca palaeothermometer was calibrated against ‘modern’ (post-1963) highly correlated (R2 = 0.91) instrumental records of global sea surface temperatures, with the pre-industrial defined by nearly constant (<±0.1 °C) temperatures from 1700 to the early 1860s. Increasing ocean and land-air temperatures overlap until the late twentieth century, when the land began warming at nearly twice the rate of the surface oceans. Hotter land temperatures, together with the earlier onset of industrial-era warming, indicate that global warming was already 1.7 ± 0.1 °C above pre-industrial levels by 2020. Our result is 0.5 °C higher than IPCC estim