Les Soulèvements de la Terre

Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses m

A new groundbreaking German study proves that pesticides spread much further from the field than previously believed. A team of scientists led by Professor Dr. Carsten Brühl tested topsoil, vegetation, streams and puddles from 78 locations over a 180 km stretch, from remote areas in the UNESCO forests on the mountain ranges to the farmland in the Upper Rhine area. The research team detected a total of 63 pesticides. Almost all measurement sites were contaminated. Residues were found in 97% of the soil and vegetation samples, often in complex mixtures of several active ingredients. This cocktail of pesticides is especially problematic because interactions can occur and effects can be amplified. The worrying results are consistent with previous smaller-scale studies in the South Tirol area in Italy. Large scale and prolonged pesticide use is a major factor in the sharp decline in populations of insects and other organisms essential for farming, as highlighted in our biodiversity campaign. The researchers see pe

Mémoire de recherche

Qu’est-ce qu’un individu si l’être que je suis est fait de tous les êtres qui me composent et des multiples influences qui me façonnent ?

abs_empty

abs_empty

abs_empty