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Nonylphenol is a toxic xenobiotic compound classified as an endocrine disrupter capable of interfering with the hormonal system of numerous organisms. It originates principally from the degradation of nonylphenol ethoxylates which are widely used as industrial surfactants. Nonylphenol ethoxylates reach sewage treatment works in substantial quantities where they biodegrade into several by-products including nonylphenol. Due to its physical–chemical characteristics, such as low solubility and high hydrophobicity, nonylphenol accumulates in environmental compartments that are characterised by high organic content, typically sewage sludge and river sediments, where it persists.

Dans son nouveau livre, «Countdown», l'épidémiologiste environnementale et reproductive Shanna Swan prédit que le nombre de spermatozoïdes pourrait atteindre zéro d'ici 2045 grâce à des produits chimiques perturbateurs hormonaux qui sont «partout»