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Exclusive: Intelligence officers say Russian campaign could intensify ‘in months, not years’ – but that panic risks playing into Kremlin psy-ops
Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses m
What places on Earth are most resilient to global catastrophic risk (GCR)? We provide the first study of what locations are more resilient against the impacts of nuclear war, near-Earth objects, large-magnitude volcanic eruptions, large-scale cyberattacks, high altitude electromagnetic pulse, geomagnetic storms and pandemics. This shows there is no place on Earth which is resilient against all kinds of GCR. Australia shows resilience across the widest range of GCR scenarios in the literature we reviewed, but even for it, continued international cooperation and trade are essential. Across the different risks, common resilience factors that show up most are geographic isolation (e.g. islands), self-sufficiency (especially in food production), high governance quality (more democratic and lower inequality) and decentralization to mitigate single point catastrophic failures (e.g. impacting trade or food supply). Many of these factors stand in tension with each other and trade-offs are required to balance between d
Exclusive: As wildfires rage, Frank Elderson says more work needed to assess risk from collapse of ecosystem services
Farmers warn food shortages are just 10 days away – the signs suggest they’ve already arrived As farmers sound the alarm about a growing food crisis, experts say that Britain's food insecurity needs to be treated as a growing national security risk. As climate change and conflict affect fragile supply chains, the warnings are becoming impossible to ignore, writes disaster planner Lucy Easthope
Increasing instability of the ocean, ice and atmosphere threatens farming, finance and society. We all need to wake up to that fact.
The climate and nature crisis threatens all aspects of British life, from national security to the food supply. Despite the scale of the risks now facing the UK, there has been no comprehensive national emergency briefing delivered to the public by the Government.
Do we really want to play dice with our planet?
The British-Canadian computer scientist often touted as a “godfather” of artificial intelligence has shortened the odds of AI wiping out humanity over the next three decades, warning the pace of change in the technology is “much faster” than expected. Prof Geoffrey Hinton, who this year was awarded the Nobel prize in physics for his work in AI, said there was a “10% to 20%” chance that AI would lead to human extinction within the next three decades.
Les scénarios socio-économiques et les niveaux de réchauffement planétaire qui en résultent structurent la compréhension des chaines de causalité entre les émissions de gaz à effet de serre, le contrôle de la pollution atmosphérique, les changements d’usage des terres, la réponse du système Terre, les facteurs climatiques générateurs d’impacts, l’exposition, la vulnérabilité, les réponses d’adaptation, et les risques liés au climat.
Closed-door talks over the World Bank’s climate agenda have stalled, as the US pushes to scrap green targets and expand support for fossil fuels
Scenarios serve as a critical tool in climate change analysis, enabling the exploration of future evolution of the climate system, climate impacts, and the human system (including mitigation and adaptation actions). This paper describes the scenario framework for ScenarioMIP as part of CMIP7. The design process has involved various rounds of interaction with the research community and user groups at large. The proposal covers a set of scenarios exploring high levels of climate change (to explore high-end climate risks), medium levels of climate change (anchored to current policy), and low levels of climate change (aligned with current international agreements). These scenarios follow very different trajectories in terms of emissions, with some likely to experience peaks and subsequent declines in greenhouse gas concentrations in this century. An important innovation is that most scenarios are intended to be run, if possible, in emission-driven mode, providing a better representation of the Earth system uncert
Dario Amodei questions if human systems are ready to handle the ‘almost unimaginable power’ that is ‘potentially imminent’
The decline in the health of nature around the world poses a threat to the UK's security and prosperity, an intelligence committee has concluded in a long-awaited report. The document warns of "cascading risks" from the degradation of some of the planet's most important ecosystems, including conflict, migration and increased competition for resources.
Progress of artificial general intelligence could stall, which may lead to a financial crash, says Yoshua Bengio, one of the ‘godfathers’ of modern AI
Data group forecasts deficit of 10mn tonnes by 2040, equivalent to nearly one-third of current global demand
Climate regime shifts (CRSs), characterized by abrupt and persistent transitions between alternative stable states in the climate system, pose serious threats to ecosystems and human well-being. Understanding the potential drivers of CRSs is crucial, particularly in a warming world where CRSs are becoming more frequent.
Les priorités fédérales révèlent une myopie anachronique : on invoque la rigueur et l’intérêt des générations futures pour préserver les finances de l’État, tout en négligeant ces mêmes arguments face aux risques climatiques et environnementaux devenus infiniment plus menaçants.
We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petroleum-based waste and heavy metals have been discovered in pesticide and plasticizer formulations. These contaminations have now reached all forms of life. Widespread exposure to chemical mixtures promotes health and environmental risks. We discovered that pesticides have never undergone long-term testing on mammals in their full commercial formulations by regulatory authorities or the pesticide industry; instead, only their declared active ingredients have been assessed, contrary to environmental law recommendations. The ingredients of these formulations are not fully disclosed, yet the formulations are in general at least 1000 times more toxic at low environmentally relevant doses than the active ingredients alone u
Dr Luke Kemp is a Research Associate at the Centre for the Study of Existential Risk, University of Cambridge. He has a PhD in international relations from the ANU and previous experience as a senior economist at Vivid Economics. This episode explores catastrophic and extinction risk, why the topic is understudied, and how we can weigh out the catastrophic risks of climate change and solar geo-engineering.
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