English references

Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses m

It has the world's largest reserves, produces comparatively little, and has a type of oil that the US needs. […] Over the weekend, the United States bombed Venezuela, and captured its president Nicolás Maduro. There has been a lot of speculation about the legality, true motive and implications going forward. Oil has been a central part of the discussion. I wanted to get a quick overview of what the global picture looks like. So here are five(ish) simple charts that give some context on the history of oil in Venezuela, and why the United States — which is, by far, the world’s largest producer itself — would care so much.

These are difficult times indeed, with terrible news on many fronts. What are the prospects for the degrowth1 alternative as we move through 2025? Dark times: the current context First, we need to understand what is going on around us: what is the evolving context with which degrowth has to contend, and to which it has to present a viable alternative?

The escalating tensions between Pakistan and India serve as a stark reminder that climate change is no longer a distant — it is now a force multiplier for geopolitical instability. As the climate crisis accelerates, so too does its capacity to deepen existing rivalries, strain fragile agreements, and inflame long-standing disputes. In South Asia, the Indus Waters Treaty (IWT) has long been a rare success story of transboundary cooperation between two nuclear-armed neighbours. However, as both climate pressures and political tensions mount, this once-resilient agreement is beginning to show signs of severe strain. The looming question is no longer just about water rights — it’s about whether climate change could be the catalyst for the world’s first true climate war.

This report introduces an analytical framework to better understand the drivers, triggers and impacts of internal displacement in the context of climate change.