English references

Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses m

Exclusive: Federal government court filings claim internal company documents included warnings about products being toxic

According to the Associated Press, the Trump administration last week proposed a set of rollbacks that would decimate the country’s waterways. Legally, Trump can’t just undo the Biden-era rules on a whim. Instead, his EPA has started work on a convoluted workaround, which includes state-level enforcement delays and revisions to the original regulations.

Millions of Pages of Previously Classified Documents on Industrial Poisons (and Counting)

Together with the Center for International Environmental Law, we expose the scientific deception by chemicals industry which is delaying or derailing regulation to protect health and the environment.

There is mounting experimental evidence that lifetime exposure to increasing atmospheric CO2 levels can negatively impact the normal physiology of organisms. Directly assessing this in humans is very difficult. We analysed serum bicarbonate (HCO3−), calcium (Ca) and phosphorus (P) from 1999 to 2020 as indirect proxies for atmospheric CO2 exposure. Over this period, average bicarbonate levels in this population show an increasing trend which parallels rising atmospheric CO2 concentrations. Both. If these trends continue, blood bicarbonate values could be at the limit of the accepted healthy range in half a century, and Ca and P will be at the limit of their healthy ranges by the end of this century. This has the potential to cause a range of adverse health effects.

Residents report terror of smoke-filled city, from potentially toxic rain, air and water to food scarcity and difficulty of escape

Anthropogenic activities are increasing the amount of carbon dioxide (CO2) in the atmosphere. There is mounting experimental evidence that lifetime exposure to these increasing atmospheric CO2 levels can negatively impact the normal physiology of organisms. However, directly assessing this in humans is very difficult. We analysed serum bicarbonate (HCO3−), calcium (Ca) and phosphorus (P) levels from the U.S. National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020 as indirect proxies for atmospheric CO2 exposure. Over this period, average bicarbonate levels in this population show an increasing trend which parallels rising atmospheric CO2 concentrations. Both Ca and Phave decreased steadily over the same period. If these trends continue, blood bicarbonate values could be at the limit of the accepted healthy range in half a century, and Ca and P will be at the limit of their healthy ranges by the end of this century. Studies indicate that, after this time, elevated atmospheric carbon dioxide

Nonylphenol is a toxic xenobiotic compound classified as an endocrine disrupter capable of interfering with the hormonal system of numerous organisms. It originates principally from the degradation of nonylphenol ethoxylates which are widely used as industrial surfactants. Nonylphenol ethoxylates reach sewage treatment works in substantial quantities where they biodegrade into several by-products including nonylphenol. Due to its physical–chemical characteristics, such as low solubility and high hydrophobicity, nonylphenol accumulates in environmental compartments that are characterised by high organic content, typically sewage sludge and river sediments, where it persists.

A chemical that takes thousands of years to break down is found in England's freshwater fish at 1,000 times above safe levels – and could end up on our dinner tables

Toxic pollution from wildfires has infiltrated the homes of more than a billion people a year over the last two decades, according to new research. The climate crisis is driving up the risk of wildfires by increasing heatwaves and droughts, making the issue of wildfire smoke a “pressing global issue”, scientists said.

A microplastics and toxic chemicals expert says her family doesn't wear shoes at home. Microplastics from car tires and garbage, as well as street runoff, can be tracked indoors on shoes. The researcher thinks her kids' Japanese heritage helped them adopt the habit.

Springtails illustrate in new research how global warning and antibiotic resistance creates synergistic effects: warming increases pesticide toxicity, triggering antibiotic resistance which spreads through horizontal gene transfer and predation.

Metals and metalloids are ubiquitous in soils, originating from bedrock and from human activities and infrastructure. These compounds can be toxic to humans and other organisms, and their soil distribution and concentrations at global scale are not well known. Hou et al. analyzed data from more than 1000 regional studies to identify areas of metal toxicity and explore drivers of these trends. They estimate that 14 to 17% of cropland exceeds agricultural thresholds for at least one toxic metal.

Microplastics have been found for the first time in human ovary follicular fluid, raising a new round of questions about the ubiquitous and toxic substances’ potential impact on women’s fertility. The new peer-reviewed research published in Ecotoxicology and Environmental Safety checked for microplastics in the follicular fluid of 18 women undergoing assisted reproductive treatment at a fertility clinic in Salerno, Italy, and detected them in 14.

Major mapping project reveals PFAS have been found at high levels at thousands of sites across Europe. EURACTIV's media partner, The Guardian, reports. Pollutants known as “forever chemicals”, which don’t break down in the environment, build up in the body and may be toxic, have been found at high levels at thousands of sites across the UK and Europe, a major mapping project has revealed.

The multibillion-dollar chemicals company 3M told customers its firefighting foams were harmless and biodegradable when it knew they contained toxic substances so persistent they are now known as “forever chemicals” and banned in many countries including the UK, newly uncovered documents show.

The fate, effects, and treatment of per- and polyfluoroalkyl substances (PFAS), an anthropogenic class of chemicals used in industrial and commercial production, are topics of great interest in recent research and news cycles. This interest stems from the ubiquity of PFAS in the global environment as well as their significant toxicological effects in humans and wildlife. Research on toxicity, sequestration, removal, and degradation of PFAS has grown rapidly, leading to a flood of valuable knowledge that can get swamped out in the perpetual rise in the number of publications. Selected papers from the Journal of Hazardous Materials between January 2018 and May 2022 on the toxicity, sequestration, and degradation of PFAS are reviewed in this article and made available as open-access publications for one year, in order to facilitate the distribution of critical knowledge surrounding PFAS. This review discusses routes of toxicity as observed in mammalian and cellular models, and the observed human health effects i

Guardian investigation finds 98% of Europeans breathing highly damaging polluted air linked to 400,000 deaths a year

Recent leaks from oil sands tailings ponds have contaminated water, sowing mistrust among local First Nations people