English references

Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses m

Exclusive: High-level documents show how Copa Cogeca worked to weaken legislation to protect climate and wildlife

In a landmark paper, the UN Special Rapporteur on Environmental Defenders warns that the continued State efforts to repress and criminalise environmental protests, including direct action and civil disobedience, are a threat to fundamental freedoms and democracy itself.

How Cynicism Became the New Psychological Performance

Scenarios serve as a critical tool in climate change analysis, enabling the exploration of future evolution of the climate system, climate impacts, and the human system (including mitigation and adaptation actions). This paper describes the scenario framework for ScenarioMIP as part of CMIP7. The design process has involved various rounds of interaction with the research community and user groups at large. The proposal covers a set of scenarios exploring high levels of climate change (to explore high-end climate risks), medium levels of climate change (anchored to current policy), and low levels of climate change (aligned with current international agreements). These scenarios follow very different trajectories in terms of emissions, with some likely to experience peaks and subsequent declines in greenhouse gas concentrations in this century. An important innovation is that most scenarios are intended to be run, if possible, in emission-driven mode, providing a better representation of the Earth system uncert

Environment News: UNITED NATIONS: Vanuatu will renew its climate justice fight at the United Nations General Assembly with a draft resolution that was watered down afte.

Le philosophe de l'environnement Rupert Read dit à Ella Whelan la panéliste Moral Maze pourquoi nous ne pourrons peut-être plus profiter du même niveau de vie pour le bien de la planète et des générations futures.

Olivier De Schutter says new economic agenda needed to tackle crises of rising inequality and ecological collapse

Residents report terror of smoke-filled city, from potentially toxic rain, air and water to food scarcity and difficulty of escape

Neonicotinoid insecticides are a major driver of pollinator decline. Due to their persistence and mobility in soil, they can contaminate non-target vegetation through runoff or dust, reaching pollinator resources. However, predicting soil contamination is challenging, especially where pesticide use data is lacking. This study assessed the potential of using proxies such as cropping history and landscape structure to predict neonicotinoid content in soils. We analyzed seven neonicotinoids in 86 sites in agricultural landscapes of Belgium.

Ecosystem destruction will increase food shortages, disorder and mass migration, with effects already being felt

Melting glaciers, coastal areas wiped off the map and regular 40C heat in Europe. Climate experts warn the gloomy predictions of long term environmental change are no longer the future - they are already here. Last year was the third hottest on record, with the World Meteorological Organization this week warning that 2025 continued a run of “extraordinary” global temperatures. The EU has said the Paris climate agreement of 1.5C could be broken before 2030, a decade sooner than expected.

The Environmental Protection Agency is moving forward with approvals for pesticides containing “forever chemicals” as an active ingredient, dismissing concerns about health and environmental impacts raised by some scientists and activists. This month, the agency approved two new pesticides that meet the internationally recognized definition for per- and polyfluoroalkyl substances, also known as PFAS or fluorinated substances, and has announced plans for four additional approvals.

There is rising concern that several parts of the Earth system may abruptly transition to alternative stable states in response to anthropogenic climate and land-use change. Key candidates of such tipping elements include the Greenland Ice Sheet, the Atlantic Meridional Overturning Circulation, the South American monsoon system and the Amazon rainforest. Owing to the complex dynamics and feedbacks between them via oceanic and atmospheric coupling, the levels of anthropogenic forcing at which transitions to alternative states can be expected remain uncertain. Here we demonstrate how such interactions can generate spurious signals and potentially mask genuine signs of destabilization. We further review and present observation-based evidence that the stability of these four tipping elements has declined in recent decades, suggesting that they have moved towards their critical thresholds, which may be crossed within the range of unmitigated anthropogenic warming. Our results call for better monitoring of these ti

Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale’, a report by 160 scientists from 23 countries warns

This paper analyses General Social Survey (United States) data and provides evidence that the advent of Facebook and other social media platforms has widened the gap in scepticism towards science between low-educated Americans and their more highly educated counterparts. The same trend holds true when considering distrust in medicine, the press and television. Overall, the results suggest that education may serve as a protective factor against the influence of fake news, disinformation and misinformation. Additionally, a heterogeneity analysis shows that the increase in distrust is particularly pronounced among young people. Further analyses reveal that political affiliation plays a role in shaping attitudes towards science and that the likelihood of voting for the Republican Party has increased among low-educated individuals. A comprehensive set of robustness and placebo tests supports the reliability of these findings.

A California outfit has used artificial intelligence to design viral genomes before they were then built and tested in a laboratory. Following this, bacteria was then successfully infected with a number of these AI-created viruses, proving that generative models can create functional genetics. "The first generative design of complete genomes." That's what researchers at Stanford University and the Arc Institute in Palo Alto called the results of these experiments. A biologist at NYU Langone Health, Jef Boeke, celebrated the experiment as a substantial step towards AI-designed lifeforms, according to MIT Technology Review. "They saw viruses with new genes, with truncated genes, and even different gene orders and arrangements," Boeke said.

The White House has instructed NASA employees to terminate two major, climate change-focused satellite missions. As NPR reports, Trump officials reached out to the space agency to draw up plans for terminating the two missions, called the Orbiting Carbon Observatories. They've been collecting widely-used data, providing both oil and gas companies and farmers with detailed information about the distribution of carbon dioxide and how it can affect crop health.

Forests have historically acted as a reliable planetary thermostat. They regulate Earth’s temperature by removing carbon dioxide (CO2) from the atmosphere and locking it in trees, roots and soil — carbon that is emitted if trees are cut down. In a typical year, forests and other vegetation absorb roughly 30% of the carbon that humans emit from burning fossil fuels — a vital climate service performed at virtually no cost by trees around the world, from tropical rainforests to temperate and boreal forests.

Climate misinformation campaigns have shifted tactics, a comprehensive new analysis shows.