English references

Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses m

Today, we are close to the critical moment when conventional economic growth becomes impossible on a finite planet, constrained by two parallel factors: resource depletion and pollution. Tthe depletion of fossil fuels and other mineral commodities is placing heavy constraints on both industrial and agricultural production. We are not running out of anything yet, but the cost of extraction is increasing, just as the damage that extraction causes to the ecosystem. On the other side, pollution is appearing in more than one form. Chemical pollution is growing in terms of heavy metals, endocrine-disruptors, and other poisoning substances, while climate change can be seen as another form of pollution generated by the excess of CO2 in the atmosphere.

Named one of the “world’s ten most influential intellectuals” by MIT, Douglas Rushkoff is an author and documentarian who studies human autonomy in a digital age. Rushkoff’s work explores how different technological environments change our relationship to narrative, money, power, and one another. He coined such concepts as “viral media,” “screenagers,” and “social currency,” and has been a leading voice for applying digital media toward social and economic justice. In the conversation we talk about the power of ideas, our disconnection from reality, going meta, ancestral fears, tech billionaires mindset and how they are preparing for the apocalypse. We also reflect on the urgent need to be more human and reconnect with what is essential.

Since Donald Trump's presidential election victory, major tech companies have abandoned years of policies restricting military work and sought out lucrative defense contracts and deeper connections with the Pentagon.

Metals and metalloids are ubiquitous in soils, originating from bedrock and from human activities and infrastructure. These compounds can be toxic to humans and other organisms, and their soil distribution and concentrations at global scale are not well known. Hou et al. analyzed data from more than 1000 regional studies to identify areas of metal toxicity and explore drivers of these trends. They estimate that 14 to 17% of cropland exceeds agricultural thresholds for at least one toxic metal.

Atrazine is an herbicide widely used on plantations worldwide. Experimental studies suggest that the herbicide impairs male reproductive function in mammals. This systematic review and meta-analysis aimed to evaluate the impact of atrazine exposure on the levels of hormones from the hypothalamic-pituitary-testicular axis using murine as the animal model. After an extensive literature search, we selected 25 articles for the systematic review.

Fear appeals are a polarizing issue, with proponents confident in their efficacy and opponents confident that they backfire. We present the results of a comprehensive meta-analysis investigating fear appeals' effectiveness for influencing attitudes, intentions, and behaviors. We tested predictions f …

An investigation by conservationists has found evidence that deep-seabed mining of rare minerals could cause “extensive and irreversible” damage to the planet.The report, to be published on Monday by the international wildlife charity Fauna & Flora, adds to the growing controversy that surrounds proposals to sweep the ocean floor of rare minerals that include cobalt, manganese and nickel. Mining companies want to exploit these deposits – which are crucial to the alternative energy sector – because land supplies are running low, they say.

This study evaluates how Europe can fulfil its goal of “achieving resource security” and “reducing strategic dependencies” for its energy transition metals, through a demand, supply, and sustainability assessment of the Green Deal and its resource needs.

Reaching climate neutrality by 2050 will require 35 more times lithium and up to 26 more times the amount of rare metals compared to today’s limited use, according to a study by a team of researchers from the Belgian university KU Leuven. The study “Metals for Clean Energy” was commissioned by Eurometaux, Europe’s association of metal producers.

Metals will play a central role in successfully building Europe’s clean technology value chains and meeting the EU’s 2050 climate-neutrality goal. In the wake of supply disruptions from the COVID-19 pandemic and Russia's invasion of Ukraine, Europe’s lack of resilience for its growing metals needs has become a strategic concern. This study evaluates how Europe can fulfil its goal of “achieving resource security” and “reducing strategic dependencies” for its energy transition metals, through a demand, supply, and sustainability assessment of the EU Green Deal and its resource needs . It concludes that Europe has a window of opportunity to lay the foundation for a higher level of strate- gic autonomy and sustainability for its strategic metals through optimised recycling, domestic value chain investment, and more active global sourcing. But firm action is needed soon to avoid bottlenecks for several materials that risk being in global short supply at the end of this decade.

To this day, the demand for metals has kept increasing. The energy transition necessary to meet climate objectives will add to that demand during the upcoming decades, for low-carbon energy technologies require larger metal quantities than their fossil-fuel based counterparts. This frequently raises concerns over the actual capacity of geological stocks to meet demand at scale, which we investigate in the present analysis.

Low greenhouse gas technologies require more metals than their fossil fuel-based counterparts. This column estimates supply elasticities and pins down the price impact of the energy transition on the metals markets. The results show that prices for copper, nickel, cobalt, and lithium could reach historical peaks for an unprecedented, sustained period in a net zero emissions scenario. The total value of production could rise more than four-fold for the period 2021-2040, rivaling the total value of crude oil production.

The massive and growing ‘forever chemicals’ scandal in Belgium marks the culmination and possible endpoint of the endless growth logic, not to mention the privatising of profit and the socialising of costs. This was reflected in the leaked secret settlement, reached in 2018, between a Flemish government-owned company (Lantis) and a mega-multinational (3M), which leaves the taxpayers footing the bill, currently estimated at €63 million, for just a small part of the enormous PFOS pollution that seeped into the soil and water around the 3M plant in Zwijndrecht.