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We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petroleum-based waste and heavy metals have been discovered in pesticide and plasticizer formulations. These contaminations have now reached all forms of life. Widespread exposure to chemical mixtures promotes health and environmental risks. We discovered that pesticides have never undergone long-term testing on mammals in their full commercial formulations by regulatory authorities or the pesticide industry; instead, only their declared active ingredients have been assessed, contrary to environmental law recommendations. The ingredients of these formulations are not fully disclosed, yet the formulations are in general at least 1000 times more toxic at low environmentally relevant doses than the active ingredients alone u

22 of the planet’s 34 vital signs are at record levels, with many of them continuing to trend sharply in the wrong direction. This is the message of the sixth issue of the annual “State of the climate” report. The report was prepared by an international coalition with contribution from the Potsdam Institute for Climate Impact Research (PIK) and led by Oregon State University scientists. Published today in BioScience, it cites global data from the Intergovernmental Panel on Climate Change (IPCC) in proposing “high-impact” strategies.

Collapse has historically benefited the 99%. […] That’s the amazing conclusion of Luke Kemp, author of Goliath’s Curse: The History and Future of Societal Collapse.  Luke is a research associate at the Centre for the Study of Existential Risk at the University of Cambridge, and has spent the past five years studying the collapse of civilisations throughout history. He joins me to explain his research, detailing the difference between complex, collective civilisations and what he calls “Goliaths”, massive centralising forces by which a small group of individuals extract wealth from the rest through domination and the threat of violence. Today, he says, we live in a global Goliath.

A California outfit has used artificial intelligence to design viral genomes before they were then built and tested in a laboratory. Following this, bacteria was then successfully infected with a number of these AI-created viruses, proving that generative models can create functional genetics. "The first generative design of complete genomes." That's what researchers at Stanford University and the Arc Institute in Palo Alto called the results of these experiments. A biologist at NYU Langone Health, Jef Boeke, celebrated the experiment as a substantial step towards AI-designed lifeforms, according to MIT Technology Review. "They saw viruses with new genes, with truncated genes, and even different gene orders and arrangements," Boeke said.

Purpose Animal emissions account for nearly 60% of total greenhouse gas emissions from the livestock sector. To estimate these emissions, the Food and Agriculture Organization of the United Nations (FAO) developed a dedicated module within the Global Livestock Environmental Assessment Model (GLEAM). Although previous studies have explored selected inputs for specific animals and emission types, a comprehensive analysis of all 92 inputs (parameters and emission factors) had not been conducted. This study aimed to identify the most influential inputs affecting ruminant emissions in GLEAM.

Heat waves that already affect the population of the Metropolitan Area of Barcelona (AMB) could significantly intensify in the future, with temperature increases of up to 6ºC and a general reduction in relative humidity in cities by the end of the century.

Guardian investigation finds almost 7,000 proven cases of cheating – and experts says these are tip of the iceberg

Fifteen years ago, smack in the middle of Barack Obama's first term, amid the rapid rise of social media and a slow recovery from the Great Recession, a professor at the University of Connecticut issued a stark warning: the United States was heading into a decade of growing political instability.

Legal residents of the United States sent to foreign prisons without due process. Students detained after voicing their opinions. Federal judges threatened with impeachment for ruling against the administration’s priorities. In the Opinion video above, Marci Shore, Timothy Snyder and Jason Stanley, all professors at Yale and experts in authoritarianism, explain why America is especially vulnerable to a democratic backsliding — and why they are leaving the United States to take up positions at the University of Toronto.

Previous health impact assessments of temperature-related mortality in Europe indicated that the mortality burden attributable to cold is much larger than for heat. Questions remain as to whether climate change can result in a net decrease in temperature-related mortality. In this study, we estimated how climate change could affect future heat-related and cold-related mortality in 854 European urban areas, under several climate, demographic and adaptation scenarios. We showed that, with no adaptation to heat, the increase in heat-related deaths consistently exceeds any decrease in cold-related deaths across all considered scenarios in Europe. Under the lowest mitigation and adaptation scenario (SSP3-7.0), we estimate a net death burden due to climate change increasing by 49.9% and cumulating 2,345,410 (95% confidence interval = 327,603 to 4,775,853) climate change-related deaths between 2015 and 2099. This net effect would remain positive even under high adaptation scenarios, whereby a risk attenuation of 50%

Emerging infectious diseases, biodiversity loss, and anthropogenic environmental change are interconnected crises with massive social and ecological costs. In this Review, we discuss how pathogens and parasites are responding to global change, and the implications for pandemic prevention and biodiversity conservation. Ecological and evolutionary principles help to explain why both pandemics and wildlife die-offs are becoming more common; why land-use change and biodiversity loss are often followed by an increase in zoonotic and vector-borne diseases; and why some species, such as bats, host so many emerging pathogens. To prevent the next pandemic, scientists should focus on monitoring and limiting the spread of a handful of high-risk viruses, especially at key interfaces such as farms and live-animal markets. But to address the much broader set of infectious disease risks associated with the Anthropocene, decision-makers will need to develop comprehensive strategies that include pathogen surveillance across s

The story of Greenland keeps getting greener—and scarier. A new study provides the first direct evidence that the center—not just the edges—of Greenland's ice sheet melted away in the recent geological past and the now-ice-covered island was then home to a green, tundra landscape.

Under current emission trajectories, temporarily overshooting the Paris global warming limit of 1.5 °C is a distinct possibility. Permanently exceeding this limit would substantially increase the probability of triggering climate tipping elements. Here, we investigate the tipping risks associated with several policy-relevant future emission scenarios, using a stylised Earth system model of four interconnected climate tipping elements.

For many of us the climate crisis mainly calls to mind rising global temperatures, but the crisis goes far beyond this – we are at risk of pushing our planet across climate ‘tipping points,’ critical thresholds where small changes can lead to abrupt and irreversible shifts in the Earth’s climate system. One major element in climate tipping is a huge system of ocean currents, the Atlantic Meridional Overturning Circulation (AMOC), which is responsible for Europe's relatively mild climate. Past climate patterns show that these currents can switch abruptly between today’s vigorous flow and a much weaker flow state. A future shutdown would have potentially devastating consequences in Europe and around the world.

L’augmentation des niveaux de CO2 atmosphérique actuelle est 10 fois plus rapides qu’à tout moment au cours des 50 000 dernières années.